Santiago de Cuba won its first Cuban National Series in 1980, edging Villa Clara as well as Forestales and Vegueros (both from Pinar del Río Province).
| Team | W | L | Pct. | GB |
|---|---|---|---|---|
| Santiago de Cuba | 35 | 16 | .686 | - |
| Villa Clara | 34 | 17 | .666 | 1 |
| Forestales | 33 | 18 | .647 | 2 |
| Vegueros | 33 | 18 | .647 | 2 |
| Industriales | 31 | 20 | .607 | 4 |
| Sancti Spíritus | 31 | 20 | .607 | 4 |
| Metropolitanos | 30 | 20 | .6 | 4½ |
| Holguín | 28 | 21 | .571 | 6 |
| Henequeneros | 28 | 21 | .571 | 6 |
| Citricultores | 25 | 24 | .510 | 9 |
| Cienfuegos | 26 | 25 | .509 | 9 |
| Granma | 22 | 29 | .431 | 13 |
| Camagüey | 21 | 30 | .411 | 14 |
| Guantánamo | 18 | 33 | .352 | 17 |
| Ciego de Ávila | 18 | 33 | .352 | 17 |
| La Habana | 17 | 32 | .346 | 17 |
| Las Tunas | 12 | 38 | .24 | 22½ |
| Isla de la Juventud | 12 | 39 | .235 | 23 |
| West League | East League |
| Group A Isla de la Juventud | Matanzas Metropolitanos (Havana) | Pinar del Río |
Group C Camagüey | Ciego de Ávila Las Tunas | Villa Clara |
| Group B Cienfuegos | La Habana Province Industriales (Havana) | Sancti Spíritus |
Group D Granma | Guantánamo Holguín | Santiago de Cuba |
| Defunct teams: Agricultores | Azucareros | Citricultores | Forestales | Ganaderos | Granjeros Henequeneros | Mineros | Occidentales | Oriente/Orientales | Vegueros |
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| Seasons: 1961-62 | 1962-63 | 1963-64 | 1964-65 | 1965-66 | 1966-67 | 1967-68 | 1968-69 | 1969-70 | 1970-71 | 1971-72 | 1972-73 | 1973-74 | 1974-75 | 1975-76 | 1976-77 | 1977-78 | 1978-79 | 1979-80 | 1980-81 | 1981-82 | 1982-83 | 1983-84 | 1984-85 | 1985-86 | 1986-87 | 1987-88 | 1988-89 | 1989-90 | 1990-91 | 1991-92 | 1992-93 | 1993-94 | 1994-95 | 1995-96 | 1996-97 | 1997-98 | 1998-99 | 1999-2000 | 2000–01 | 2001–02 | 2002–03 | 2003–04 | 2004–05 | 2005–06 | 2006–07 | 2007–08 | 2008–09 | 2009–10 | 2010–11 | |